Orlistat for obesity benefits beyond weight loss.
A group of researchers led by Dr. Steven A. Lusane, MD, of Brigham and Women's Hospital, Boston, reviewed all obesity studies on the effectiveness of a long-term statin for patients with high cholesterol. Overweight and obese patients were divided into two groups: One was given niacin and the other a statin.
During the trials, no patients switched to the statin due concerns about side effects.
The first trial was designed to test the safety of niacin vs. a statin. One of the primary goals was to measure changes in LDL cholesterol. After taking both drugs for three-to-six months, the researchers recorded that LDL cholesterol decreased orlistat weight loss success story from about 100, to 90, 70 60. A statin drug has been known to lower LDL cholesterol.
The statin, however, had a greater effect on LDL cholesterol than the niacin drug.
Another trial, designed to test the effectiveness of cholesterol lowering for heart failure, found that, even after six months of treatment, patients taking the statin did not reduce heart attacks or strokes compared to patients taking the niacin pill.
The researchers concluded that statins were better alternatives, in addition to diet and exercise, for reducing cardiovascular risk.
Dr. Lusane cautioned, however, that the benefits of statins, including preventing heart attacks and strokes, are not limited to obese patients.
He noted, "What we've shown is that the effectiveness of statins, if you start out in a normal-weight and overweight patient with high LDL cholesterol, you start out just slightly better and then with a lot of further therapy, the risk death is a lot lower. The benefits are not limited to the obese. There are benefits for patients of all sizes. People with no risk factors can do as much or more good than people with diabetes and cardiovascular disease. But people with a very high risk of mortality, the results for high LDL cholesterol are just not as good with other cardiovascular risks."
Other experts said the results of new research are interesting and important.
Dr. Gary Taubes, co-author of the book "Diet for a Hot and Flaming Health" director of research for the non-profit advocacy group Center for Science in the Public Interest and an associate professor of nutrition and epidemiology public health at the University of California, Los Angeles, said, "What's most interesting here is that the difference between statins and placebo is actually very small. We all know the difference between a placebo and real treatment. Statins were just as effective. They might even be more Tadalafil doc generici effective for some people. The fact that placebo effects are so strong, but they were just not seen with statins suggests that there are ways for treating obesity by using other approaches, like lifestyle."
Dr. Taubes said that he has seen no real downside to statins and that patients who do not respond to them die of cardiovascular disease. "Statins are the gold standard of treatment in the medical community," he explained.
Dr. Lusane echoed these views. However, he says the new data raise some concerns.
"We're also concerned about how the drug is taken. niacin taken orally so you need to make sure you're not putting it in your eyes or you don't have the stomach upset. It needs to be swallowed. We know very little about the long-term side effects. Are there any long-term harms. We want to make sure there are no risks, but obviously people who take statins for a long time have some concerns. I know there have been reports of statin abuse."
Dr. Lusane noted that most of the research into statins came out of trials looking at the cholesterol lowering effects of drugs. However, the new study used statin to measure long-term effects of statins as a treatment for heart disease.
According to Dr. Lusane, more clinical trials are needed to examine the long-term effects of statins. He said that even long-term studies are complicated because patients often change how they measure their cholesterol and how they take the medication at different times, which results in a confusing picture.
It is not yet known if the same will hold true for the new study.
Another question the researchers wanted to answer was whether long-term statin use would have any effect on the risk of developing cancer. If so, would the side effects of statins outweigh any reduction in risk of cancer?
The team wanted to assess that question because they knew statin therapy lowers LDL cholesterol but not high-density lipoproteins (HDL), which help prevent heart disease.
According to Dr. Lusane, there are two potential mechanisms in which statins might increase risk of cancer. The first is that they might increase levels of certain.
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Weight loss by orlistat to Dr. Mark Hyman (Dr.Mark) in his recent letter to the Journal of American College Cardiology.
The loss of weight is not due to a lack of weight and/or eating. The patient lost more weight by doing exercise. Here is how I explained it in a previous post. the exercise was about 20 minutes per day. In some of his patients he did 100 minutes per day, which is very hard to maintain. With orlistat they did 4,000mg per day instead of 20 min per day for about 7 months, which is like taking 150mg a day, not 10 doses per week, but instead the dose may change every week. It is still a significant extra dose and does not help much with weight orlistat and weight loss loss. The number of loss has doubled to 12 pounds over this period.
He is a cardiologist, so I have no reason to say more.
(3) The lack of response by other doctors is probably not due to lack of knowledge about this drug. There is study in Mayo Clinic Proceedings, but there are no other studies in the mainstream medical literature.
Here are two reports on orlistat in The Lancet with no data from other studies.
Here is a 2011 report, with comment by the authors (and no other studies) that says:
It is unclear whether the improved cardiac Diclofenac sodium 50mg tablets price outcomes Buy fluoxetine 20 mg uk reported by IOM are specific to orlistat or attributable other factors in the study (for example, to improved control of diabetes), or perhaps to the effects of allopregnanolone rather than to orlistat. However, as is usual for new treatments it will take time orlistat weight loss drug to assess the safety and benefits of allopregnanolone in addition to orlistat primary care. In my early days as a freelancer, once every other week or two, I'd be the first to answer a call. Someone on the other end wanted a project and I'd show up—usually with a fresh proposal—at least week before it usually got built (and I never paid for my work). It's funny how we all look back on those times and wonder if we handled things a bit better. But I always managed to manage show up. If I had my way, we'd be doing this every week now. I think I'm better, and you should too!
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