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Cost of doxycycline hyclate 50 mg /g (Table 7) is much higher than that cost doxycycline uk of the comparators in Table 7 [4, 5]. This difference is mainly due to the higher cost of doxycycline hyclate 50 mg/g (at the same concentration), which we estimate to cost approximately $2.80/dose. Although the of doxycycline hydrochloride is significantly lower than that of doxycycline hyclate, in this instance, we believe that the price difference justifies additional cost of doing so. A higher cost for doxycycline hyclate is likely due to higher manufacturing costs (including the of preservative additives), use a proprietary, high-quality formulation, and the use of a new, more expensive and labor-intensive formulation. Table Is phenergan available over the counter in australia 7. Comparison of the cost doxycycline Hydrochloride and doxycycline/hydroxyprogesterone, respectively, when purchased per dosage unit for a total of 8 doses: Pharmacy Price per canada pharmacy generic viagra tablet $0.08 dose Product Cost per $0.09 tablet $0.15 dose Product Cost per tablet $0.17 dose Product Cost per tablet $0.26 dose Product Cost per tablet $0.37 dose Product Cost per tablet $0.42 dose Product Cost per tablet $0.51 dose Product Cost per tablets $0.54 dose Product Cost per package $0.67 dose Drug Price per tablet $0.10 Product Cost dose per $0.05 tablet $0.08 Product Cheap doxycycline capsules Cost per dose tablet $0.12 Product Cost per dose tablet $0.16 Product Cost per dose package $0.20 Product Cost per dose package $0.30 Product Cost per dose package $0.36 Product Cost per dose package $0.39 Patient Cost per dose $0.20 package $0.45 Product Cost per Doxycycline 150mg $58.12 - $0.97 Per pill dose bag $1.10 Patient Cost per dose package $0.65 Product Cost per dose tablet $1.55 Consumer Cost per dose $0.75 package $1.55 Consumer Cost per dose package $1.75 CONCLUSION We found that: (i) Pharmacists should generally avoid substituting generic doxycycline for the branded brand because there are some important differences. (ii) There is no reason to use the generic doxycycline substitute for branded when the product dosage is same and the cost of either product is comparable. The generic doxycycline available from manufacturers at a lower cost per dose and the generic formulation is less susceptible to contaminants, whereas the branded generic doxycycline contains additives that can affect its therapeutic efficacy. (iii) Pharmacies can use the brand name formulation as a generic option, even at the expense of significant savings to consumers. We believe that these findings are relevant to clinical practice and should be incorporated in clinical practice guidelines, particularly as regards prescribing information on the cost-effectiveness of generic doxycycline. Our findings are consistent with other studies that have shown consumers are willing to pay more for generic antibiotics [10, 11]. The findings of our study reinforce the notion that cost and quality differences between generic branded antibiotics may have a cost of generic doxycycline substantial impact on patient adherence and compliance rates; the results also confirm that current practice of substituting generic for branded antibiotics by physicians must be reconsidered. ACKNOWLEDGMENT We are indebted to the participating pharmacy practices for their participation in th