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In the first case, a very strong and active alkaloid of the kykeon-type is digested. This product not as active a base the first one but possesses a high proportion of the compound and has opposite physical property from the above mentioned. This second salt produces a highly concentrated product with long duration of action on the nervous systems of experimental animals. The dose first and second product is the same. In experiments with monkeys this product had some hypnotic action.
The compound may be prepared synthetically from the alkaloid kykeon or with other alkaloids, a procedure which is possible with kykeon but not any of the derivatives kykeon.
For the production of products produced by the reaction of aqueous sodium kykeon with boric acid and in the preparation of product obtained from the reaction of kykeon with bicarbonate soda there is used in the process from 100 to 200 milliliter of boric acid at the temperature of 20° C., or 300 to 400 milliliter of sodium kykeon or kyakon with boric acid at the temperature of 25° to 27° C. for the first reaction. reaction using kykeon with boric acid and the bicarbonate of soda a much larger quantity of boric acid is used because it has a higher heat of decomposition and hence a longer time of action. In the experiments with monkeys first product the average dosage was 200 mg, and for the second dose was 300 mg. In the experiments of rats with first product the dosage was 300 mg. In the experiments with monkeys this dosage is found to be about 300 mg.
In the experiments with monkeys average dosage is about 300 mg.
As far is known from the experiments with monkeys following physical properties are observed with the first salt of kykeon, which is produced synthetically from kykeon according to the procedures mentioned previously:
It is an extremely active base; a high concentration is found in it, which approximately three times that of the acid; it may be prepared with the same reaction as first one, but the amount of compound used is the same. It in physical state of kykeon, which may be either alkaline or neutral. The physical properties observed in this product are similar, but a little different, than those of the first salt kykeon.
The compound may be prepared synthetically from the alkaloid or other alkaloids, a procedure which is possible with kykeon or any of the derivatives kykeon. It is also possible to prepare the product by reaction of bicarbonate soda with sodium or kykeon boric acid at the temperature of 25 to 27 degrees C.
As regards the nature of this product, physical properties which are observed the same as those with first salt of kykeon, except that it has a longer action of several hours and a higher dosage.
The compound may also be prepared synthetically with alkali carbonate or acetic acid the other alkaloid of type kykeon or with other alkaloids any of the compounds following types:
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